反应详情

2,4-Dichlorofuro[3,2-d]pyrimidine 37 (23 mg, 1.0 eq) was suspended in methanol (1.7 ml) and treated with morpholine (0.09 ml, 4.0 eq). Reaction mixture was stirred at room temperature for 2 h, before being quenched with saturated aq. NaHCO3. Mixture was extracted with dichloromethane. The combined organic layers were dried (Na2SO4) and concentrated to yield 2-chloro-4-morpholinofuro[3,2-d]pyrimidine 38 (14 mg, 48%) which was used in the next reaction without further purification.

1. customReaction mixture
2. custombefore being quenched with saturated aq. NaHCO3
3. extractionMixture was extracted with dichloromethane
4. dry with materialThe combined organic layers were dried (Na2SO4)
5. concentrationconcentrated