n,n-Dimethylpiperazine-1-carboxamide → HCID 86623516, compound

HRID 881270Notes

Reaction equation

HRID 881270 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]2[S:10][C:9]([CH:11]=O)=[C:8]([CH3:13])[C:6]=2[N:7]=1.[CH3:20][N:21]([CH3:30])[C:22]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)=[O:23]>>[CH3:20][N:21]([CH3:30])[C:22]([N:24]1[CH2:25][CH2:26][N:27]([CH2:11][C:9]2[S:10][C:5]3[C:4]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)=[N:3][C:2]([Cl:1])=[N:7][C:6]=3[C:8]=2[CH3:13])[CH2:28][CH2:29]1)=[O:23]

Participants

3

Reactant 2

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 566485822-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 86623516HCID 86623516, compound

Procedure

Reaction between 2-chloro-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and piperazine-1-carboxylic acid dimethylamide (Example 26) using General Procedure B-3 yielded 4-(2-chloro-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid dimethylamide.

Sources & evidence

ORD record
ord-4ee7cdd98c3f41a188cd5ff44f9c11bf
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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