4-Methanesulfonylpiperidine hydrochloride → 2-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	4-Methanesulfonylpiperidine hydrochloride	HCID 23061698	—
Reactant	2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde	HCID 45789985	—
Product	2-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine	HCID 57494044	—

Reaction Steps

4-Methanesulfonyl-piperidine hydrochloride salt was reacted with 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 following General Procedure B-3. Purification on silica yielded 2-chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08993563B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-e14ca81c460b4119897d8d8a468898ea
Source note	uspto-grants-2015_03