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HRID881283

反应详情

EQUATION

反应方程式

HRID 881283 的结构方程式

REACTANTS

反应物

3
结构：OB(O)c1cccnc1
HCID2734378

3-Pyridinylboronic acid

C5H6BNO2

结构：CS(=O)(=O)C1CCNC1
HCID3419356

3-(methylsulfonyl)pyrrolidine

C5H11NO2S

结构：O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1
HCID45789985

2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine-6-carbaldehyde

C11H10ClN3O2S

PRODUCTS

生成物

1
结构：CS(=O)(=O)C1CCN(Cc2cc3nc(-c4cccnc4)nc(N4CCOCC4)c3s2)C1
HCID24947794

未命名化合物

PROCEDURE

实验过程

2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde 10 from Example 3 (100 mg) was reacted with 3-(methanesulfonyl)pyrrolidine following the protocol in General Procedure C. One half of the crude material was then used with pyridine-3-boronic acid in General Procedure A to give 47 mg of 141 following reversed phase HPLC purification. MS (Q1) 460 (M)+.