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A 10 mL rb flask equipped with a magnetic stir bar and a septum was charged with a solution of 50 mg (0.11 mmol) of the product of Example 90, in 2 mL MeOH, 24 mg (0.27 mmol) of manganese dioxide and ca. 5 mg of sodium cyanide was added. The reaction mixture was stirred at room temperature for 4 h, then filtered and evaporated in vacuo. The residue was purified on a silica gel flash chromatography column eluted with 0–10% EtOAc-hexane. Evaporation of the purified fractions and drying in vacuo afforded the title compound. HPLC/MS: 482.2 (M+1), 484.0 (M+3); Rt=4.57 min.

1. customA 10 mL rb flask equipped with a magnetic stir bar
2. filtrationfiltered
3. customevaporated in vacuo
4. customThe residue was purified on a silica gel flash chromatography column
5. washeluted with 0–10% EtOAc-hexane
6. customEvaporation of the purified fractions
7. customdrying in vacuo