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HRID881313

反应详情

EQUATION

反应方程式

HRID 881313 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2cnc(N)nc2)OC1(C)C
HCID17750212

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

C10H16BN3O2

结构：Cc1c(CN2CCN(C(=O)CO)CC2)sc2c(N3CCOCC3)nc(Cl)nc12
HCID86623518

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(CN2CCN(C(=O)CO)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12
HCID56648758

未命名化合物

收率 10.1%

PROCEDURE

实验过程

1-(4-((2-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone (60 mg) was reacted with 34 mg of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure A. The product was purified by reverse phase HPLC to yield 6.9 mg of 178. MS (Q1) 485.1 (M)+

WORKUP

后处理

  1. customThe product was purified by reverse phase HPLC