Lactic Acid → HCID 86623521, compound

HRID 881318Notes

Reaction equation

HRID 881318 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:5]2[CH:10]=[C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:8][C:6]=2[N:7]=1.[C:24](O)(=[O:28])[CH:25]([CH3:27])[OH:26]>>[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[C:5]2[CH:10]=[C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:24](=[O:28])[C@@H:25]([OH:26])[CH3:27])[CH2:14][CH2:13]3)[S:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 612Lactic AcidHCID 56833848HCID 56833848, compound

Product 1

HCID 86623521HCID 86623521, compound

Procedure

2-Chloro-4-morpholino-6-((piperazin-1-yl)methyl)thieno[2,3-d]pyrimidine (600 mg) was reacted with lactic acid via General Procedure B to give (S)-1-(4-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one.

Sources & evidence

ORD record
ord-b25cc18f6b93462c8e970cf0a9caada8
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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