2-Methoxypyrimidine-5-boronic acid → 2-(2-methoxypyrimidin-5-yl)-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxypyrimidine-5-boronic acid	HCID 2736778	—
Reactant	2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine	HCID 56833744	—
Product	2-(2-methoxypyrimidin-5-yl)-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidine	HCID 58233957	—

Reaction Steps

2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine (Example 153) was reacted with 2-methoxypyrimidine-5-boronic acid via General Procedure E to give, after purification by reverse HPLC, 4 mg of 237. MS (Q1) 490 (M+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08993563B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-ee29a9abb2844270a2cad21301cdb16c
Source note	uspto-grants-2015_03