反应详情

温度

80 °C

To a solution of 236 (1.0 eq) in acetonitrile (0.1M) at r.t. was added chlorosulfonyl isocyanate (10 eq) dropwise. The reaction was stirred for 40 minutes, then concentrated. To the residue was added 2N HCl and mixture was heated to 80° C. for 20 minutes. Reaction mixture was allowed to cool down to room temperature, and was neutralized with NaOH 6M. Mixture was then concentrated. The crude product was purified by reverse phase HPLC to give 6 mg of 247. MS (Q1) 517 (M+

1. concentrationconcentrated
2. additionTo the residue was added 2N HCl and mixture
3. customReaction mixture
4. temperatureto cool down to room temperature
5. concentrationMixture was then concentrated
6. customThe crude product was purified by reverse phase HPLC