HRID881432

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17750212

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

C10H16BN3O2

结构：CC(c1cc2nc(Cl)nc(N3CCOCC3)c2s1)N1CCN(S(C)(=O)=O)CC1

HCID86618431

未命名化合物

PRODUCTS

生成物

结构：CC(c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1)N1CCN(S(C)(=O)=O)CC1

HCID58234066

未命名化合物

PROCEDURE

实验过程

2-Chloro-6-[1-(4-methanesulfonyl-piperazin-1-yl)-ethyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 2-aminopyrimidine-5-boronic acid pinacol ester in General Procedure A. Purification on silica yielded 300. NMR: (CDCl3): 1.44 (3H, d, J 7.1, Me), 2.52-2.64 (4H, m, CH2), 2.73 (3H, s, Me), 3.21-3.23 (4H, m, CH2), 3.80-3.83 (4H, m, CH2), 3.94-4.06 (5H, m), 5.16 (2H, s, NH2) and 9.20 (2H, s, Ar). MS: (ESI+): MH+=505.20

WORKUP

后处理

customPurification on silica