HRID881458

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57416439

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine

C11H15BF3N3O2

结构：Cc1c(CN2CCN(C(=O)C(C)O)CC2)sc2c(N3CCOCC3)nc(Cl)nc12

HCID86623548

未命名化合物

PRODUCTS

生成物

HCID57416439

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine

C11H15BF3N3O2

结构：Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3C(F)(F)F)nc12

HCID58233939

未命名化合物

PROCEDURE

实验过程

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-4-trifluoromethyl-pyrimidin-2-ylamine was prepared according to WO2007/084786. 110 mg of 1-[4-(2-Chloro-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-2-hydroxy-propan-1-one, prepared as in Example 118, was coupled to 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-4-trifluoromethyl-pyrimidin-2-ylamine via General Procedure A to yield 20 mg of 325 MS (Q1) 567.2 (M)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5fd23ef602824c3db2c758def2117b7b
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08993563B2
来源说明: uspto-grants-2015_03

反应 SMILES

Cl[C:2]1[N:3]=[C:4]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18](=[O:22])[CH:19]([OH:21])[CH3:20])[CH2:14][CH2:13]3)=[C:8]([CH3:23])[C:6]=2[N:7]=1.[CH3:30][C:31]1([CH3:49])[C:35]([CH3:37])([CH3:36])[O:34][B:33]([C:38]2[C:39]([C:45]([F:48])([F:47])[F:46])=[N:40][C:41]([NH2:44])=[N:42][CH:43]=2)[O:32]1>>[CH3:36][C:35]1([CH3:37])[C:31]([CH3:30])([CH3:49])[O:32][B:33]([C:38]2[C:39]([C:45]([F:46])([F:47])[F:48])=[N:40][C:41]([NH2:44])=[N:42][CH:43]=2)[O:34]1.[NH2:44][C:41]1[N:40]=[C:39]([C:45]([F:48])([F:46])[F:47])[C:38]([C:2]2[N:3]=[C:4]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:5]3[S:10][C:9]([CH2:11][N:12]4[CH2:17][CH2:16][N:15]([C:18](=[O:22])[C@@H:19]([OH:21])[CH3:20])[CH2:14][CH2:13]4)=[C:8]([CH3:23])[C:6]=3[N:7]=2)=[CH:43][N:42]=1