Sodium borohydride → (5-Bromopyridin-2-yl)methanol

To a solution of 5-bromopyridine-2-carbaldehyde (300 mg) in methanol (10 mL) was added sodium borohydride (61 mg) and the reaction stirred at room temperature for 72 h. The reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL) and extracted into dichloromethane (3×30 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-methanol as a white solid.

1. customThe reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL)
2. extractionextracted into dichloromethane (3×30 mL)
3. dry with materialThe organic layers were dried (MgSO4)

ORD record

ord-2837ac9766f6442d9bad4d64a0c97964

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08993563B2