Sulfuric Acid → HCID 59734932, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated sulfuric acid (0.335 mL, 5.70 mmol) was added to a solution of tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate (310 mg, 0.712 mmol) in H2O (2 mL) and the mixture heated to 60° C. After 2.5 h, the reaction mixture was quenched with saturated aqueous NaHCO3. The mixture was extracted with CH2Cl2 (3×), and the combined organic extracts were washed with water, saturated brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give the title compound. MS: m/z=322 (M+1).

Provenance & Evidence