Sodium Hydroxide → HCID 72188386, compound

Participants

Reaction Steps

To a mixture of methyl 2-(4-(4-(5-(5-cyclobutyl-1,3,4-oxadiazol-2-ylamino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate (38 mg, 0.08 mmol) and THF (1 ml) was added NaOH (0.24 ml, 0.24 mmol). The mixture was stirred at room temperature for 7 hour. The resulting content was concentrated and purified on prep-HPLC to afford the title compound as white solid after drying (15 mg, 41% yield). HR/MS (M+H)+ found 461.2188. calc. 461.2184. RT: 5.63 (Condition Z). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.85-2.13 (m, 10H) 2.27-2.40 (m, 6H) 3.69 (quind, J=8.43, 8.43, 8.43, 8.43, 0.88 Hz, 1H) 3.91 (s, 2H) 7.41 (d, J=8.59 Hz, 2H) 7.90-8.01 (m, 3H) 8.10 (dd, J=8.59, 2.78 Hz, 1H) 8.75 (d, J=3.03 Hz, 1H)

Provenance & Evidence