Potassium Phosphate, Tribasic → Methyl 2-(4-(4-(2-aminopyrimidin-5-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate

Participants

Reaction Steps

To a reaction vial containing methyl 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate (200 mg, 0.52 mmol), 5-bromopyrimidin-2-amine (108 mg, 0.62 mmol) and K3PO4 (132 mg, 0.62 mmol) was added dimethoxyethane (4.8 ml). The mixture was stirred at room temperature and degassed after the addition of EtOH (1.6 ml) and water (0.64 ml). PdCl2(dppf) DCM adduct (21 mg, 0.03 mmol) was added and the mixture was heated to 8° C. in an oil bath for 3 hours. The reaction mixture was then concentrated to dryness and taken up in DCM. The slurry was dried over sodium sulfate and filtered through a pad of celite. The filtrate was concentrated and purified by column chromatography to afford the title compound (193 mg, 84% yield). LC/MS, ESI-MS(+): 354.3, RT: 1.06 (Condition E).

Provenance & Evidence