Sodium Hydroxide → HCID 89872226, compound

Participants

Reaction Steps

The title compound was prepared analogous to Example 4, Step 5 starting from methyl 2-(4-(4′-((5-cyclopropyl-1,3,4-oxadiazol-2-yl)amino)-[1,1′-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate (413 mg, 0.90 mmol) and NaOH (2.70 ml, 2.70 mmol). After completion of the reaction, the mixture was concentrated to dryness and taken up in water. The resulting slurry was filtered and washed with water to afford the title compound as white solid after drying (392 mg, 93% yield). HR/MS (M+H)+ found 446.2077. calc. 446.2080. RT: 1.54 (Condition L). 1H NMR (400 MHz, DMSO-d6) δ ppm 10.54 (br. s., 1H) 7.58-7.64 (m, 4H) 7.55 (d, J=8.34 Hz, 2H) 7.36 (d, J=8.34 Hz, 2H) 3.84 (s, 2H) 2.16-2.27 (m, 2H) 2.13 (tt, J=8.37, 5.02 Hz, 1H) 2.00 (s, 2H) 1.88-1.99 (m, 2H) 1.69-1.88 (m, 4H) 1.03-1.10 (m, 2H) 0.91-0.98 (m, 2H)

Provenance & Evidence