Hydrochloric Acid → HCID 72188426, compound

Participants

Reaction Steps

To a reaction vial contaminions 2-(4-(4′-((5-cyclopropyl-1,3,4-oxadiazol-2-yl)amino)-[1,1′-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetic acid sodium salt (195 mg, 0.42 mmol) was added water (5 ml). The mixture was stirred and hydrochloric acid was added dropwise until the entire mixture achieved a pH between 3 and 4. The resulting slurry was filtered, washed with water to afford the title compound as white solid after drying (183 mg, 99% yield). HR/MS (M+H)+ found 446.2070. calc. 446.2080. RT: 1.66 (Condition L). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.01 (br. s, 1H) 10.43 (s, 1H) 7.52-7.67 (m, 6H) 7.38 (d, J=8.59 Hz, 2H) 3.89 (s, 2H) 2.32 (s, 2H) 2.08-2.19 (m, 1H) 1.79-2.07 (m, 8H) 1.02-1.12 (m, 2H) 0.91-0.99 (m, 2H).

Provenance & Evidence