Sodium Hydroxide → HCID 72188433, compound

Participants

Reaction Steps

The title compound was prepared analogous to Example 4, Step 4 starting from methyl 2-(4-(4′-(5-isobutyl-1,3,4-oxadiazol-2-ylamino)biphenyl-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate (56 mg, 0.12 mmol) and NaOH (0.35 ml, 0.35 mmol). After acidification with 1N HCl, the slurry was filtered and washed with water to afford the title compound as white solid after drying (52 mg, 97% yield). HR/MS (M+H)+ found 462.2399. calc. 462.2406. RT: 2.40 (Condition L). 1H NMR (400 MHz, DMSO-d6) δ ppm 10.02-10.86 (m, 1H) 7.62 (s, 5H) 7.53-7.59 (m, 2H) 7.37 (d, J=8.59 Hz, 2H) 3.85 (s, 2H) 2.65 (d, J=7.07 Hz, 2H) 2.11-2.25 (m, 2H) 2.00-2.09 (m, 3H) 1.90-2.00 (m, 2H) 1.81 (d, J=13.39 Hz, 4H) 0.97 (d, J=6.82 Hz, 6H)

Provenance & Evidence