HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester → 4-(2-Methyl-benzothiazol-6-yl)-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester | HCID 67505910 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Methyl-benzothiazol-6-yl)-butyric acid methyl ester | HCID 67505708 | — |
Reaction Steps
Next, a solution of (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester in THF (10 mL) is hydrogenated over 10% Pd/C (22 mg, 10% wet) at 1 atm for 48 hours. The catalyst is filtered through Celite and the solvent is removed under reduced pressure. The residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give 4-(2-methyl-benzothiazol-6-yl)-butyric acid methyl ester. MS 250.4 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993631B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5a02eb9f38714c3bb73e37f4582536a1 |
| Source note | uspto-grants-2015_03 |