Propylene Oxide → HCID 89463680, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound methyl 3-hydroxy-5-methoxybenzoate (Example 1, step i, 90 mg, 0.5 mmol) and propylene oxide (120 mg, 2 mmol) in DMF (2 ml) was added K2CO3 (280 mg, 2 mmol). The reaction mixture was stirred at 100° C. overnight. After cooling to ambient temperature, the mixture was filtered and the filtrate was concentrated under reduced pressure. The obtained residue was purified using normal phase chromatography, eluting with petroleum ether containing 50% ethyl acetate to give (R)-methyl 3-(2-hydroxypropoxy)-5-methoxybenzoate (100 mg).

Provenance & Evidence