Ammonium formate → HCID 89464462, compound

Participants

Reaction Steps

A solution of N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(benzoxy)-5-methoxybenzamide (Example 11, step iv, 1.45 g, 2.5 mmol), ammonium formate (0.70 g, 11.1 mmol) and 10% palladium on carbon (0.15 g) in methanol (30 ml) was heated to reflux temperature for 18 hours. The reaction mixture was cooled to ambient temperature and filtered through celite. The filtrate was concentrated under reduced pressure and the residue obtained was partitioned between CH2Cl2 and water. The organic phase was passed through a hydrophobic frit and concentrated under reduced pressure to give N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-hydroxy-5-methoxybenzamide as a pale yellow foam (1.16 g). MS (ESI) me: 485.6 (M+H)+.

Provenance & Evidence