Water → HCID 131732639, compound

Participants

Reaction Steps

A solution of 4-N-Boc-aminomethylpiperidine (25 g, 120 mmol), 2,4-Dichloro-1,3,5-Triazine (20 g, 140 mmol) and DIPEA (77.4 g, 600 mmol) in CH3CN (300 ml) was stirred at room temperature for 2 hours. Water was added and the product was extracted into ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The crude residue that was purified using normal phase chromatography, eluting with petroleum ether containing 30% ethyl acetate to give tert-butyl (1-(4-chloro-1,3,5-triazin-2-yl)piperidin-4-yl)methylcarbamate as an off white solid (30.0 g).

Provenance & Evidence