Hydrochloric Acid → HCID 89713532, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-methyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pentanoate (251 mg, 1.08 mmol) and Me(MeO)NH.HCl (157 mg, 1.61 mmol) were added to anhydrous THF (3 mL) and the mixture was cooled to −20° C. under nitrogen charge. An i-PrMgCl solution (1.62 mL, 2.0 M) dissolved in THF was slowly added thereto over 15 min by using a syringe. The mixture was further stirred at −10° C. for 20 min, and then a saturated NH4Cl aqueous solution (2 mL) was added thereto to complete the reaction. Extraction was performed by using ethyl acetate, anhydrous magnesium sulfate was used to perform drying and distillation under reduced pressure, and then column chromatography was used to obtain 270 mg (yield 93%) of the title compound.

Provenance & Evidence