Ammonium Chloride → HCID 86691336, compound

Participants

Reaction Conditions

Reaction Steps

LiCl (7.00 mg, 0.159 mmol) and Pd(PPh3)4 (2.30 mg, 0.002 mmol) were added to anhydrous Et2O (1 mL), and then the resulting solution was cooled to 0° C. A solution obtained by dissolving 3-(hydroxymethyl)-5-methylhex-1-ene-2-yl trifluoromethanesulfonate (11 mg, 0.0398 mmol) in anhydrous Et2O (1 mL) was slowly added thereto and the resulting solution was stirred for 10 min. TMSCH2MgCl (0.119 mL, 0.119 mmol, 1.0 M/Et2O solution) was slowly added thereto, the resulting solution was stirred for 1 hr, and then a saturated NH4Cl aqueous solution (1 mL) was added thereto to complete the reaction. The temperature was increased to normal temperature, extraction was performed by using ethyl acetate (3×3 mL), distillation was performed under reduced pressure, and then column chromatography was used to obtain 8.03 mg (yield 94%) of the title compound.

Provenance & Evidence