8-Hydroxyquinoline → tert-Butyl 9-methyl-2-(2-oxo-4-(6-(trifluoromethyl)pyridin-3-yl)pyridin-1(2H)-yl)-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 2-bromo-9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3′,4′:4,5]pyrrolo[2,3-b]pyridine-6-carboxylate (0.80 g, 2.2 mmol), 4-(6-(trifluoromethyl)pyridin-3-yl)pyridin-2(1H)-one (0.58 g, 2.4 mmol), and Cs2CO3 (0.78 g, 2.4 mmol) were suspended in DMSO (13 mL), and the air was removed under vacuum for 15 min. The system was flushed with Ar, and 8-hydroxyquinoline (95 mg, 0.65 mmol) and copper iodide (0.54 g, 2.8 mmol) were added to the suspension. The evacuation/Ar flushing process was repeated twice more, and the reaction mixture was heated at 130° C. for 18 h under N2. The mixture was cooled, diluted with 5.0:3.5:1.5 NH4Cl(aq.)/NH4OH/H2O (70 mL), and the resulting suspension was stirred at ambient temperature for 30 min. The resulting solids were collected by filtration, dissolved in CH2Cl2 (30 mL) and washed with 5.0:3.5:1.5 NH4Cl(aq.)/NH4OH/H2O (2×30 mL). Activated charcoal was added to the organic solution, and the resulting suspension was filtered through a Celite® plug and concentrated to dryness under reduced pressure. Flash chromatography (40 g ISCO column, (1:1 hexanes/EtOAc)/(80:18:2 CH2Cl2/MeOH/NH4OH), 100:0 for 4 column volumes, increased to 50:50 over 12 column volumes and held for 4 column volumes; increased to 0:100 over 10 column volumes and held for 4 column volumes) gave the title compound (0.82 g, 71%) as a yellow solid: 1H NMR (500 MHz, DMSO-d6) δ 9.20 (d, J=1.5 Hz, 1H), 8.50 (dd, J=8.5, 2.0 Hz, 1H), 8.08-8.05 (m, 3H), 7.39 (d, J=8.5 Hz, 1H), 7.03 (d, J=1.5 Hz, 1H), 6.84 (dd, J=7.0, 2.0 Hz, 1H), 4.59 (s, 2H), 3.77 (t, J=5.5 Hz, 2H), 3.70 (s, 3H), 2.90 (t, J=5.5 Hz, 2H), 1.45 (s, 9H).

Provenance & Evidence