HRID882070

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57950360

未命名化合物

结构：CC(C)(C)OC(=O)N1CCc2nc3cc(Br)ccn3c2C1

HCID67988849

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCc2nc3cc(-n4ccc(OCc5ccc(C(F)(F)F)nc5)cc4=O)ccn3c2C1

HCID68056129

未命名化合物

收率 44%

PROCEDURE

实验过程

tert-Butyl 7-bromo-3,4-dihydropyrido[4′,3′:4,5]imidazo[1,2-a]pyridine-2(1H)-carboxylate (175 mg, 0.498 mmol) and 4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridin-2(1H)-one (134 mg, 0.498 mmol) were reacted according to Example 18 (step g) to provide the title compound (104 mg, 44%) as a yellow solid: ESI MS m/z 542 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4158e8e8446427da830ad08f795738a
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08993765B2
来源说明: uspto-grants-2015_03

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][N:5]2[C:8]3[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:12][CH2:11][C:9]=3[N:10]=[C:4]2[CH:3]=1.[F:22][C:23]([F:40])([F:39])[C:24]1[N:29]=[CH:28][C:27]([CH2:30][O:31][C:32]2[CH:37]=[CH:36][NH:35][C:34](=[O:38])[CH:33]=2)=[CH:26][CH:25]=1>>[O:38]=[C:34]1[CH:33]=[C:32]([O:31][CH2:30][C:27]2[CH:28]=[N:29][C:24]([C:23]([F:40])([F:22])[F:39])=[CH:25][CH:26]=2)[CH:37]=[CH:36][N:35]1[C:2]1[CH:7]=[CH:6][N:5]2[C:8]3[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:12][CH2:11][C:9]=3[N:10]=[C:4]2[CH:3]=1