1,4-Dioxane → HCID 86683822, compound

Participants

Reaction Steps

Selenium dioxyde (50 mg, 0.45 mmol, 1.3 eq) in suspension in dioxane (1 mL) was heated at 60° C. The 6-bromo-7-dimethylamino-2-methylquinoline-8-carbonitrile (100 mg, 0.34 mmol, 1.0 eq) was then introduced and the mixture was left to react at 80° C. for 3 hours. After cooling to room temperature, the mixture was filtered on celite, eluted with dioxane and concentrated under reduced pressure. The crude product was precipitated from ether to afford 6-bromo-7-dimethylamino-2-formylquinolin-8-carbonitrile as an orange powder (74 mg, 72%).

Provenance & Evidence