HCID 123358842, compound → HCID 89630145, compound

Participants

Reaction Steps

To a solution of 4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (12.0 g, 32.4 mmol) in methanol (200 mL), was added Pd/C (2.00 g, 10 wt. %). The reaction was then purged with hydrogen gas and stirred overnight at room temperature under hydrogen atmosphere (1 atm) before being filtered and concentrated in vacuo. The reaction was then purified by chromatography using silica gel, eluting with 50% EtOAc/petroleum ether. The product was collected and concentrated in vacuo to afford 3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline as a yellow oil. LRMS (ESI) calc'd for C18H25N4OSi [M+H]+: 341, found 341.

Provenance & Evidence