Ethylenediamine → HCID 89630021, compound

Participants

Reaction Conditions

Reaction Steps

To N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide (140 mg, 0.295 mmol) was added portionwise, a solution of trifluoroacetic acid (3.4 g, 30 mmol) in dichloromethane (10 mL). The reaction was stirred for 1 hour at 50° C., then concentrated in vacuo. To this crude reaction mixture was added ethane-1,2-diamine (35 mg, 0.59 mmol), followed by portionwise addition of a solution of sodium hydroxide (82 mg, 2.1 mmol) in methanol (10 mL). After stirring at room temperature for 30 minutes, the reaction mixture was concentrated in vacuo and extracted with ethyl acetate (×3). The combined organic layers were washed with brine, dried with anhydrous sodium sulfate, filtered and concentrated in vacuo. Purification of the crude product by reverse phase HPLC using an acetonitrile gradient in water with 0.5% TFA modifier afforded N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide as a green solid. LRMS (ESI) calc'd for C19H16N5O2 [M+H]+: 346, found 346. 1H NMR (400 MHz, CD3OD) δ 9.05 (s, 1H), 8.25 (s, 1H), 7.93 (s, 1H), 7.80 (d, 1H, J=8.0 Hz), 7.59 (s, 1H), 7.38-7.42 (m, 1H), 7.26 (d, J=8.0 Hz, 1H), 7.13 (s, 1H), 5.80 (s, 1H), 5.55 (s, 1H), 1.99 (s, 3H).

Provenance & Evidence