HCID 89630068, compound → HCID 89615616, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)oxazole (175 mg, 0.400 mmol) in methanol (5 mL), was added Pt/C (200 mg, 1 wt. % on carbon, Vanadium doped). The atmosphere was then purged with hydrogen gas, and the resulting solution was stirred under hydrogen atmosphere (1 atm) for 3 hours at 25° C. The reaction was filtered and the filtrate concentrated in vacuo to afford crude 3-(5-(oxazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline as a solid. LRMS (ESI) calc'd for C21H26N5O2Si [M+H]+: 408, found 408.

Provenance & Evidence