Hydrochloric Acid → HCID 131732648, compound

Participants

Reaction Steps

A suspension of tert-butyl (2-(4-((2S,4R)-1-acetyl-2-methyl-4-(pyridin-2-ylamino)-1,2,3,4-tetrahydroquinolin-6-yl)benzamido)ethyl)carbamate (for a preparation see Intermediate 40)(35 mg, 0.064 mmol) in 1,4-dioxane (1 mL) at room temperature was treated with hydrogen chloride in 1,4-dioxane (4N, 2 mL, 8.00 mmol) and the resulting suspension was stirred for 1 h at this temperature then concentrated in vacuo. The residue was triturated with Et2O the solid isolated by filtration and dried under house vacuum to give 4-((2S,4R)-1-acetyl-2-methyl-4-(pyridin-2-ylamino)-1,2,3,4-tetrahydroquinolin-6-yl)-N-(2-aminoethyl)benzamide, hydrochloride (30 mg, 0.062 mmol, 97% yield) as a very pale yellow solid. LCMS (HpH, 2 min), Rt=0.74 min, MH+=444.

Provenance & Evidence