Hydrochloric Acid → HCID 70976538, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl (2-{[(4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}phenyl)carbonyl]amino}ethyl)carbamate (for a preparation see Intermediate 45) (57 mg, 0.099 mmol) in 1,4-dioxane (0.5 mL) at room temperature was treated with hydrogen chloride in 1,4-dioxane (2 mL, 8.0 mmol) and the resulting mixture was stirred at room temperature for 1.5 h then concentrated in vacuo. The residue was co-evaporated with Et2O to give 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}-N-(2-aminoethyl)benzamide (32.5 mg, 0.063 mmol, 64.1% yield) hydrochloride as a pale yellow solid. LCMS (HpH, 2 min), Rt=1.01 min, MH+=477.

Provenance & Evidence