Water → HCID 23079586, compound

HRID 882324Notes

Reaction equation

HRID 882324 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]1([CH3:17])[NH:14][C:13](=[O:15])[NH:12][C:11]1=[O:16].[OH-].[Na+].O.NC(C)(CC1C=CC=CC=1OC)C(O)=[O:24]>C(#N)C>[C:13]([NH:14][C:10]([CH3:17])([CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1])[C:11]([OH:24])=[O:16])(=[O:15])[NH2:12]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 4013516HCID 4013516, compoundHCID 23079584HCID 23079584, compound

Product 1

HCID 23079586HCID 23079586, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

First, 4.40 g of 5-(2-methoxyphenylmethyl)-5-methyl-hydantoin was mixed with 2.64 g of sodium hydroxide and 3.5 g of water, and the mixture was subjected to reaction at 94° C. to 96° C. for 30 hours. The HPLC analysis (column: COSMOSIL 5C18-ARII (produced by Nacalai Tesque Inc.), mobile phase: acetonitrile/10 mM aqueous potassium dihydrogen phosphate solution=20/80, flow rate: 1.0 ml/min, detection wavelength: 210 nm, column temperature: 40° C.) of the reaction mixture showed the production of the title compound, 2-amino-3-(2-methoxyphenyl)-2-methyl propionic acid, and the raw material at an area ratio of 78.8:5.5:15.5.

Workup

  1. customthe mixture was subjected to reaction at 94° C. to 96° C. for 30 hours

Sources & evidence

ORD record
ord-fe16829941154dfd9614fc9e12f97f29
Source dataset
uspto-grants-2015_03
Patent number
US08993800B2

Reaction notes

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