HCID 67317226, compound → HCID 25255697, compound

HRID 882402Notes

Reaction equation

HRID 882402 reaction equation
[CH2:1]([CH:4]([CH2:27][CH2:28][CH3:29])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH:24]=[CH:25][CH:26]=1)[O:10][CH2:11][CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:2][CH3:3]>CCOCC>[CH2:27]([CH:4]([CH2:1][CH2:2][CH3:3])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH:24]=[CH:25][CH:26]=1)[O:10][CH2:11][CH2:12][NH2:13])[CH2:28][CH3:29]

Participants

3

Reactant 1

HCID 67317226HCID 67317226, compound

Product 1

HCID 25255697HCID 25255697, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Deprotection of 2-(2-(3-(2-propylpentyloxy)phenoxy)ethyl)isoindoline-1,3-dione following the method used in Example 18 gave Example 25 as a colorless oil. Yield (0.11 g, 82%): 1H NMR (400 MHz, DMSO) δ 7.11 (t, J=8.0 Hz, 1H), 6.42-6.48 (m, 3H), 3.85 (t, J=5.6 Hz, 2H), 3.78 (d, J=6.0 Hz, 2H), 2.81 (t, J=6.0 Hz, 2H), 1.65-1.75 (m, 1H), 1.48 (brs, 2H), 1.20-1.40 (m, 8H), 0.85 (t, J=7.2 Hz, 6H).

Workup

  1. customYield (0.11 g, 82%)

Sources & evidence

ORD record
ord-3d2a6e0eb3434640b0718bfeaaf1e4d0
Source dataset
uspto-grants-2015_03
Patent number
US08993807B2

Reaction notes

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