HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(benzyloxy)pentyl Methanesulfonate → 2-(2-(3-(5-Benzyloxypentoxy)phenoxy)ethyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(benzyloxy)pentyl Methanesulfonate | HCID 44627117 | — |
| Reactant | 2-[2-(3-Hydroxy-phenoxy)-ethyl]-isoindole-1,3-dione | HCID 58027534 | — |
| Product | 2-(2-(3-(5-Benzyloxypentoxy)phenoxy)ethyl)isoindoline-1,3-dione | HCID 67316420 | — |
Reaction Steps
Alkylation reaction of phenol 24 with methanesulfonic acid 5-benzyloxypentyl ester gave 2-(2-(3-(5-benzyloxypentoxy)phenoxy)ethyl)isoindoline-1,3-dione as yellow oil. Yield (1.0 g, 62%): 1H NMR (400 MHz, CDCl3) δ 7.84-7.87 (m, 2H), 7.70-7.73 (m, 2H), 7.25-7.40 (m, 5H), 7.09-7.14 (m, 1H), 6.42-6.48 (m, 3H), 4.50 (s, 2H), 4.20 (t, J=5.8 Hz, 2H), 4.10 (t, J=5.6 Hz, 2H), 3.90 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.0 Hz, 2H), 3.48 (t, J=6.0 Hz, 2H), 1.40-1.80 (m, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993807B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-8c7b6b724f694c7797355064ab1e9cc7 |
| Source note | uspto-grants-2015_03 |