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HRID882524

反应详情

EQUATION

反应方程式

HRID 882524 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：C[C@@H]1C[C@@H](Cc2ccc(-c3ccccc3)cc2)N(C(=O)C(C)(C)C)C1=O
HCID66738857

(3R,5S)-5-([1,1′-Biphenyl]-4-ylmethyl)-1-(2,2-dimethyl-1-oxopropyl)-3-methyl-2-pyrrolidinone

C23H27NO2

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H](C)C[C@H](N)Cc1ccc(-c2ccccc2)cc1
HCID25017087

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

1 g (3R,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one (2-a, R1=H), 10 ml ethanol and 0.4 ml concentrated sulphuric acid were heated at about 80-120° C. for about 24 hours. The mixture was evaporated to dryness to obtain (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (hydrogen sulphate salt). Spectroscopic data as in Example 44.

WORKUP

后处理

  1. customThe mixture was evaporated to dryness