Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 882707Generated: October 26, 2026

Rosiglitazone → Pioglitazone, (R)-

https://huagongshe.com/reaction/882707

Reaction equation

Participants

RoleNameHCIDCharge
ReactantRosiglitazoneHCID 77999—
Reactant(E)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dioneHCID 14211277—
ProductPioglitazone, (R)-HCID 29010894—

Reaction Steps

Biocatalytic reduction of 5-[1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-thiazolidine-2,4-dione was investigated using literature procedures described for Rosiglitazone (J. Chem. Soc. Perkin Trans. I, 1994, 3319-3324).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08236786B2
Source datasetuspto-grants-2012_08
ORD IDord-a1d64ffa47914ff0add7c2fa22c7cfca
Source noteuspto-grants-2012_08