Benzonitrile, 4-bromo- → HCID 57968593, compound

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Reaction Steps

The title compound was prepared from 4-bromobenzonitrile and (2R,4R)-2-(4-cyclobutyl-[1,4]diazepane-1-carbonyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester as described for Example 59. MS (ESI): mass calcd. for C26H36N4O4, 468.27; m/z found, 469.4 [M+H]+. 1H NMR (CDCl3): 7.66-7.51 (m, 2H), 6.99-6.86 (m, 2H), 5.05-4.85 (m, 1H), 4.79-4.54 (m, 1H), 4.12-3.96 (m, 1H), 3.84-3.41 (m, 4H), 2.93-2.77 (m, 1H), 2.75-2.13 (m, 5H), 2.10-1.54 (m, 10H), 1.50-1.40 (m, 9H).

Provenance & Evidence