HCID 131722148, compound → 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid

HRID 8828Notes

Reaction equation

HRID 8828 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([CH2:11][C@H:12]([CH3:23])[C:13]([O:15]CC2C=CC=CC=2)=[O:14])(=[O:10])=[O:9])[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([S:8]([CH2:11][C@H:12]([CH3:23])[C:13]([OH:15])=[O:14])(=[O:10])=[O:9])[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 131722148HCID 131722148, compound

Product 1

HCID 287101093-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A 100 mL Fisher/Porter vessel was charged with benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate in 15 mL MeOH with a catalytic amount of 10% Pd—C. Hydrogenation at 50 psi for 48 hours afforded, after filtration through Celite and concentration in vacuo to yield 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid as a hygroscopic foam suitable for use without further purification.

Workup

  1. customHydrogenation at 50 psi for 48 hours afforded
  2. filtrationafter filtration
  3. concentrationthrough Celite and concentration in vacuo

Sources & evidence

ORD record
ord-9d7628515bd341bbb48e1be9eb1b5fc1
Source dataset
uspto-grants-2006_08
Patent number
US07091219B2

Reaction notes

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