1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine dihydrochloride → 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1)
Reaction equation
[ClH:1].Cl.[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][C:30]([C:32](=[O:34])[NH2:33])=[CH:29][C:28]=3[CH:35]=2)[CH2:20][CH2:19]1)#[N:4]>O>[ClH:1].[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][C:30]([C:32](=[O:34])[NH2:33])=[CH:29][C:28]=3[CH:35]=2)[CH2:22][CH2:23]1)#[N:4]Participants
3
Procedure
10 g of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine dihydrochloride Form XIII are dispersed in 1 l water. After stirring for 48 hours the crystals are recovered by filtration, and drying in vacuo to constant weight at room temperature leads to 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride hydrate of Form V.
Workup
- filtrationare recovered by filtration
- customdrying in vacuo to constant weight at room temperature
Sources & evidence
- ORD record
- ord-df76b4fdb9944956b828edf8404a65d9
- Source dataset
- uspto-grants-2012_08
- Patent number
- US08236804B2
Reaction notes
Loading…