Nitrate(1-), oxo- → HCID 66644581, compound

HRID 882834Notes

Reaction equation

HRID 882834 reaction equation
[F:1][C:2]([F:21])([F:20])[O:3][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][CH:19]=1)[CH2:7][N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([OH:16])=O.[NH2:22][CH:23]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH:24]([OH:28])[C:25]([NH2:27])=[O:26].O[NH-].O=[N-]>>[NH2:27][C:25](=[O:26])[C:24](=[O:28])[CH:23]([NH:22][C:14]([C@H:9]1[CH2:10][CH2:11][C:12](=[O:13])[N:8]1[CH2:7][C:6]1[CH:17]=[CH:18][CH:19]=[C:4]([O:3][C:2]([F:1])([F:21])[F:20])[CH:5]=1)=[O:16])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

5

Reactant 4

HCID 3001380Nitrate(1-), oxo-HCID 138823553-Amino-2-hydroxy-4-phenylbutanamideHCID 67094950HCID 67094950, compoundHCID 178514248HCID 178514248, compound

Product 1

HCID 66644581HCID 66644581, compound

Procedure

Coupling of (R)-1-(3-trifluoromethoxy-benzyl)-5-oxo-pyrrolidine-2-carboxylic acid with 3-amino-2-hydroxy-4-phenylbutanamide and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide

Sources & evidence

ORD record
ord-f7c15bbab5fd4df99f05225d10a470d4
Source dataset
uspto-grants-2012_08
Patent number
US08236798B2

Reaction notes

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