Nitrate(1-), oxo- → HCID 66644532, compound

HRID 882836Notes

Reaction equation

HRID 882836 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C@@H:5]([C:13]([OH:15])=O)[CH2:4][CH2:3]1.[NH2:16][CH:17]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:18]([OH:22])[C:19]([NH2:21])=[O:20].O[NH-].O=[N-]>>[NH2:21][C:19](=[O:20])[C:18](=[O:22])[CH:17]([NH:16][C:13]([C@H:5]1[CH2:4][CH2:3][C:2](=[O:1])[N:6]1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:15])[CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 4

HCID 3001380Nitrate(1-), oxo-HCID 138823553-Amino-2-hydroxy-4-phenylbutanamideHCID 42260559HCID 42260559, compoundHCID 178514248HCID 178514248, compound

Product 1

HCID 66644532HCID 66644532, compound

Procedure

Coupling of (R)-5-Oxo-1-phenyl-pyrrolidine-2-carboxylic acid with 3-amino-2-hydroxy-4-phenylbutanamide and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide.

Sources & evidence

ORD record
ord-cec4da1281114705a76fa0df5a4d93d8
Source dataset
uspto-grants-2012_08
Patent number
US08236798B2

Reaction notes

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