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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 882849Generated: October 29, 2026

Nitrate(1-), oxo- → (2R)-N-(4-Amino-3,4-dioxo-1-phenylbutan-2-yl)-5-oxo-1-[2-methoxy-6-(trifluoromethyl)benzyl]pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/882849

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNitrate(1-), oxo-HCID 3001380—
Reactant3-Amino-2-hydroxy-4-phenylbutanamideHCID 13882355—
Reactant(R)-1-(2-methoxy-6-(trifluoromethyl)benzyl)-5-oxopyrrolidine-2-carboxylic acidHCID 66644853—
ReactantHCID 178514248HCID 178514248—
Product(2R)-N-(4-Amino-3,4-dioxo-1-phenylbutan-2-yl)-5-oxo-1-[2-methoxy-6-(trifluoromethyl)benzyl]pyrrolidine-2-carboxamideHCID 46944251—

Reaction Steps

Coupling of (R)-5-oxo-1-(2-methoxy-6-trifluoromethyl-benzyl)-pyrrolidine-2-carboxylic acid with 3-amino-2-hydroxy-4-phenylbutanamide and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08236798B2
Source datasetuspto-grants-2012_08
ORD IDord-9a0d4ed61089434c95d71491ee9756da
Source noteuspto-grants-2012_08