2-Thiopheneglyoxylic acid → 2(1H)-Quinoxalinone

HRID 882861Notes

Reaction equation

HRID 882861 reaction equation
CO[C:3]1[CH:4]=[C:5]([NH2:12])[C:6]([NH2:11])=[CH:7][C:8]=1OC.S1C=CC=C1[C:18](=O)[C:19](O)=[O:20]>>[NH:12]1[C:5]2[C:6](=[CH:7][CH:8]=[CH:3][CH:4]=2)[N:11]=[CH:18][C:19]1=[O:20]

Participants

3

Reactant 2

HCID 776942-Thiopheneglyoxylic acidHCID 1529391,2-Diamino-4,5-dimethoxybenzene

Product 1

HCID 145262(1H)-Quinoxalinone

Procedure

The quinoxalin-2-one of the present example is prepared with 4,5-Dimethoxy-benzene-1,2-diamine and (thiophen-2-yl)oxo-acetic acid via the method described in Example 12 to afford 6,7-Methoxy-3-thiophen-2-yl-1H-quinoxalin-2-one.

Sources & evidence

ORD record
ord-12b34cfb1d904c14a9aed73324f8ad1f
Source dataset
uspto-grants-2012_08
Patent number
US08236807B2

Reaction notes

Loading…