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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 882871Generated: October 30, 2026

2-Thiopheneglyoxylic acid → 6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one

https://huagongshe.com/reaction/882871

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Thiopheneglyoxylic acidHCID 77694—
Reactant3,4-DiaminophenolHCID 2772970—
Product6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-oneHCID 21083664—

Reaction Steps

The quinoxalin-2-one of the present example is prepared with 3,4-diaminophenol (which is prepared by treating 3,4-dinitrophenol with H2NNH2.H2O, Pd/C refluxed in MeOH), and (thiophen-2-yl)oxo-acetic acid via the method described in Example 12 to afford 6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08236807B2
Source datasetuspto-grants-2012_08
ORD IDord-86b6c3f40aed481788cec6f62bb8d5ce
Source noteuspto-grants-2012_08