Hydrochloric Acid → HCID 86656623, compound

Participants

Reaction Steps

To a solution of ((R)-1-{[(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-amino]-methyl}-butyl)-carbamic acid tert-butyl ester (0.65 g, 1.74 mmol) in 1,4-dioxane (15 mL) is added HCl (30 mL of a 4 M solution in 1,4-dioxane, 120 mmol) and the reaction mixture is stirred at RT for 16 h. The reaction mixture is concentrated in vacuo and the yellow solid obtained is triturated with diethyl ether; the ether layer is decanted and the product is dissolved in minimal MeOH and is precipitated by the addition of diethyl ether. The solvent is decanted and the resulting solid is dried under vacuum to afford the title compound. [M+H]+ 273.

Provenance & Evidence