反应详情

Methyl iodide (120 μL, 1.9 mmol) is added to a suspension of 3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid (2-dimethylamino-ethyl)-amide (Intermediate H) (100 mg, 0.39 mmol) in DCM (4 mL), and the resultant solution is stirred at RT for 2 h. The white solid which has formed is collected by filtration and washed with DCM (5 mL) to afford the title compound. M+ 273. 1H NMR (400 MHz, DMSO-d6) δ 8.27 (1H, t), 7.09 (2H, br s), 3.61 (2H, m), 3.45 (2H, t), 3.11 (9H, s).

1. customThe white solid which has formed
2. filtrationis collected by filtration
3. washwashed with DCM (5 mL)