8-Bromooctanamide → (7-Carbamoyl-heptyl)-{2-[(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-amino]-ethyl}-dimethyl-ammonium bromide

Participants

Reaction Steps

A solution of 3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid (2-dimethylamino-ethyl)-amide (Intermediate H) (100 mg, 0.39 mmol) and 8-Bromo-octanoic acid amide (Intermediate P) (130 mg, 0.6 mmol) in DMF (3 mL) is heated at 70° C. for 3 days. After this time, the solvent is removed in vacuo to yield an orange oil, which is triturated with acetone (2×10 mL) to afford the title compound. M+ 400.

Provenance & Evidence