HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Chloro-1-ethoxy-4-isocyanatobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 3-Chloro-4-ethoxyaniline | HCID 12748736 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Chloro-1-ethoxy-4-isocyanatobenzene | HCID 3015967 | — |
Reaction Steps
1-Ethoxy-2-chloro-4-isocyanato-benzene is prepared by addition of triethylamine to a solution of 4-ethoxy-3-chlorophenylamine in EtOAc at 0-5° C. Triphosgene is added and the reaction mixture is slowly heated to reflux over 2 h. The solvent is removed in vacuo and the crude product is filtered through silica to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236808B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-ae35c798b7ed4080a800857f520a5976 |
| Source note | uspto-grants-2012_08 |