Moxifloxacin hydrochloride monohydrate → Moxifloxacin hydrochloride

HRID 882995Notes

Reaction equation

HRID 882995 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].O.[ClH:31]>C(O)C(O)C>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].[ClH:31]

Participants

3

Reactant 1

HCID 9890250Moxifloxacin hydrochloride monohydrate

Product 1

HCID 101526Moxifloxacin hydrochlorideYield 85.4%

Reagents, catalysts & solvents 1

HCID 1030Propylene GlycolSolvent

Procedure

10 g of moxifloxacin hydrochloride monohydrate and 200 ml of 1,2-propandiol with 0.1% K.F. were loaded into a 250 ml flask. The mixture was brought to reflux and was kept in those conditions for 4 hours, after which it was cooled to room temperature. The solid product was filtered out and washed with 30 ml of absolute ethanol. The solid was dried under vacuum (30 mmHg) at 40° C. for 16 hours to give 8.2 g of moxifloxacin hydrochloride form A.

Workup

  1. customwere loaded into a 250 ml flask
  2. temperatureto reflux
  3. filtrationThe solid product was filtered out
  4. washwashed with 30 ml of absolute ethanol
  5. customThe solid was dried under vacuum (30 mmHg) at 40° C. for 16 hours

Sources & evidence

ORD record
ord-0887e826635f4287b0832f1d485cb1bd
Source dataset
uspto-grants-2012_08
Patent number
US08236817B2

Reaction notes

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